Correlating viral phenotypes with phylogeny: accounting for phylogenetic uncertainty

Correlating viral phenotypes with phylogeny: accounting for phylogenetic uncertainty


Joe Parker, Andrew Rambaut, Oliver G Pybus

Infection, Genetics and Evolution (2008/5/31) 8(3):239-246

Many recent studies have sought to quantify the degree to which viral phenotypic characters (such as epidemiological risk group, geographic location, cell tropism, drug resistance state, etc.) are correlated with shared ancestry, as represented by a viral phylogenetic tree. Here, we present a new Bayesian Markov-Chain Monte Carlo approach to the investigation of such phylogeny-trait correlations. This method accounts for uncertainty arising from phylogenetic error and provides a statistical significance test of the null hypothesis that
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URL: http://scholar.google.com/citations?view_op=view_citation&hl=en&oe=ASCII&citation_for_view=_WCn7AYAAAAJ:u5HHmVD_uO8C

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