The mode and tempo of hepatitis C virus evolution within and among hosts

The mode and tempo of hepatitis C virus evolution within and among hosts


Rebecca Gray, Joe Parker, Philippe Lemey, Marco Salemi, Aris Katzourakis, Oliver Pybus

BMC Evolutionary Biology (2011/5/19) 11(1):131

Background Hepatitis C virus (HCV) is a rapidly-evolving RNA virus that establishes chronic infections in humans. Despite the virus’ public health importance and a wealth of sequence data, basic aspects of HCV molecular evolution remain poorly understood. Here we investigate three sets of whole HCV genomes in order to directly compare the evolution of whole HCV genomes at different biological levels: within-and among-hosts. We use a powerful Bayesian inference framework that incorporates both among-lineage rate…
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URL: http://scholar.google.com/citations?view_op=view_citation&hl=en&oe=ASCII&citation_for_view=_WCn7AYAAAAJ:2osOgNQ5qMEC

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